Gold(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity, and Mechanistic Studies.

ABSTRACT: A series of gold(I) complexes with the general formula [Au(L2)(L')] (L2=4-phenyl-N-(prop-2-yn-1-yl)quinazoline-2-carboxamide, L'=PPh₃ (triphenylphosphine), 1; TPA (1,3,5-triaza-7-phosphaadamantane), 2, and Me₂-imy (1,3-dimethylimidazol-2-ylidene), 3) were synthesized and fully characterized by spectroscopic methods. The alkynyl ligand L2 belongs to the quinazoline carboxamide class of ligands that are known to bind to the translocator protein (TSPO) at the outer mitochondrial membrane. 1 and 2 exert cytotoxic effects in bladder cancer cells with IC₅₀ values in the low micromolar range. Further mechanistic analysis indicated that the two complexes both act by inducing reactive oxyge

SUBMITTER: Tabrizi L 

PROVIDER: S-EPMC8252463 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature