Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial.

ABSTRACT:

Background

The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences.

Study design and methods

The effects of two types of RCC (RCC-A, RCC-B) on transfusion regime were compared in a non-blinded, prospective, randomized, two-period, and crossover clinical trial. RCC-A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC-B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion-dependent thalassemia (TDT).

Results

RCC-A contained 63.9 (60.3-67.8) grams of hemoglobin per unit (median with 1^st and 3^rd quartile), RCC-B 54.5 (51.0-58

SUBMITTER: Gamberini MR 

PROVIDER: S-EPMC8252500 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature