Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.

ABSTRACT: Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, to investigate the dynamics of inflammation at the site of brain injury over time. Longitudinal transcriptional profiling of CD14⁺ monocytes/macrophages and neutrophils from hematomas of patients with ICH revealed that the myeloid response to ICH within the hematoma is distinct from that in the blood and occurs in stages conserved across the patient cohort. Initially, hematoma myeloid cells expressed a robust anabolic proinflammatory profile characterized

SUBMITTER: Askenase MH 

PROVIDER: S-EPMC8252865 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature