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Language mapping using electrocorticography versus stereoelectroencephalography: A case series.

ABSTRACT: Direct electrical stimulation (DES) is sometimes used in epilepsy surgery to identify areas that may result in language deficits if resected. Extraoperative language mapping is usually performed using electrocorticography (ECOG) - grids and strip electrodes; however, given the better safety profile of stereoelectroencephalogaphy (SEEG), it would be desirable to determine if mapping using SEEG is also effective. We report a case series of fifteen patients that underwent language mapping with either ECOG (5), SEEG (9), or both (1). Six patients in the SEEG group underwent resection or ablation with only mapping via SEEG. No patients in the SEEG group that underwent resective or ablative surgery experienced persistent language deficits. These results suggest that language mapping with SEEG may be considered as a clinically useful alternative to language mapping with ECOG.

SUBMITTER: Young JJ

PROVIDER: S-EPMC8252889 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Language mapping using electrocorticography versus stereoelectroencephalography: A case series.

Young James J JJ Coulehan Kelly K Fields Madeline C MC Yoo Ji Yeoun JY Marcuse Lara V LV Jette Nathalie N Panov Fedor F Ghatan Saadi S Bender Heidi A HA

Epilepsy & behavior : E&B 20180526

Direct electrical stimulation (DES) is sometimes used in epilepsy surgery to identify areas that may result in language deficits if resected. Extraoperative language mapping is usually performed using electrocorticography (ECOG) - grids and strip electrodes; however, given the better safety profile of stereoelectroencephalogaphy (SEEG), it would be desirable to determine if mapping using SEEG is also effective. We report a case series of fifteen patients that underwent language mapping with eith ...[more]

PMID: 29803145

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Project description:ObjectiveWe investigated intracranially-recorded gamma activity during calculation tasks to better understand the cortical dynamics of calculation.MethodsWe studied 11 patients with focal epilepsy (age range: 9-28years) who underwent measurement of calculation- and naming-related gamma-augmentation during extraoperative electrocorticography (ECoG). The patients were instructed to overtly verbalize a one-word answer in response to auditorily-delivered calculation and naming questions. The assigned calculation tasks were addition and subtraction involving integers between 1 and 17.ResultsOut of the 1001 analyzed cortical electrode sites, 63 showed gamma-augmentation at 50-120Hz elicited by both tasks, 88 specifically during naming, and 7 specifically during calculation. Common gamma-augmentation mainly took place in the Rolandic regions. Calculation-specific gamma-augmentation, involving the period between the question-offset and response-onset, was noted in the middle-temporal, inferior-parietal, inferior post-central, middle-frontal, and premotor regions of the left hemisphere. Calculation-specific gamma-augmentation in the middle-temporal, inferior-parietal, and inferior post-central regions peaked around the question offset, while that in the frontal lobe peaked after the question offset and before the response onset. This study failed to detect a significant difference in calculation-specific gamma amplitude between easy trials and difficult ones requiring multi-digit operations.ConclusionsAuditorily-delivered stimuli can elicit calculation-specific gamma-augmentation in multiple regions of the left hemisphere including the parietal region. However, the additive diagnostic value of measurement of gamma-augmentation related to a simple calculation task appears modest.SignificanceFurther studies are warranted to determine the functional significance of calculation-specific gamma-augmentation in each site, and to establish the optimal protocol for mapping mental calculation.

Dataset Information

Language mapping using electrocorticography versus stereoelectroencephalography: A case series.

Publications

Language mapping using electrocorticography versus stereoelectroencephalography: A case series.

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