ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.

ABSTRACT: Lung cancer (LC) is the leading cause of cancer-related mortality. However, the molecular mechanisms associated with the development of metastasis are poorly understood. Understanding the biology of LC metastasis is critical to unveil the molecular mechanisms for designing targeted therapies. We developed two genetically engineered LC mouse models Kras^G12D/+ ; Trp53^R172H/+ ; Ad-Cre (KPA) and Kras^G12D/+ ; Ad-Cre (KA). Survival analysis showed significantly (P = 0.0049) shorter survival in KPA tumor-bearing mice as compared to KA, suggesting the aggressiveness of the model. Our transcriptomic data showed high expression of N-acetylgalactosaminide alpha-2, 6-sialyltransferase 1 (St6galnac-I) in KPA compared to KA tumors. ST6GalNAc-I is an O-glycosyltransferase

SUBMITTER: Lakshmanan I 

PROVIDER: S-EPMC8253099 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature