Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery.

ABSTRACT:

Purpose

The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFS_free) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively.

Methods

Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFS_free, or a combination of DFS_free+DFS:IR loaded matrix films were prepared by melt-cast technology. DFS content was 20% w/w in these matrix films. In vitro transcorneal permeability from the film formulations were compared against DFS solution, using a side-by-side diffusion apparatus, over a 6 h period. Ocular disposition of DFS from the solution, films and corr

SUBMITTER: Adelli GR 

PROVIDER: S-EPMC8253122 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature