Dominant factors of the phosphorus regulatory network differ under various dietary phosphate loads in healthy individuals.

ABSTRACT:

Background

The purpose of this study was to explore the contribution of each factor of the phosphorus metabolism network following phosphorus diet intervention via Granger causality analysis.

Methods

In this study, a total of six healthy male volunteers were enrolled. All participants sequentially received regular, low-, and high-phosphorus diets. Consumption of each diet lasted for five days, with a 5-day washout period between different diets. Blood and urinary samples were collected on the fifth day of consumption of each diet at 9 time points (00:00, 04:00, 08:00, 10:00, 12:00, 14:00, 16:00, 20:00, 24:00) for measurements of serum levels of phosphate, calcium, PTH, FGF23, BALP, α-Klotho, and 1,25 D and urinary phosphorus excretion. Granger causality and the centra

SUBMITTER: Ye G 

PROVIDER: S-EPMC8253199 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature