Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis.

ABSTRACT: Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50-70% of unknown origin. Recognized causes amount to 20-50% viral infections. Approximately one third of affected subjects develops moderate and severe subsequent damage. Several neurotropic viruses can directly infect pyramidal neurons and induce neuronal death in cortex and hippocampus. The resulting encephalitic syndromes are frequently associated with cognitive deterioration and dementia, but involve numerous parallel and downstream cellular and molecular events that make the interpretation of direct consequences of sudden pyramidal neuronal loss difficult. This, however, would be pivotal for understanding how neuroinflammatory processes initiate the development of neurodegeneration, and

SUBMITTER: Wilke JBH 

PROVIDER: S-EPMC8253243 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature