Lipoprotein-Associated Phospholipase A2: A Novel Contributor in Sjogren's Syndrome-Related Lymphoma?

ABSTRACT:

Background

B-cell non-Hodgkin's lymphoma (B-NHL) is one of the major complications of primary Sjögren's syndrome (SS). Chronic inflammation and macrophages in SS minor salivary glands have been previously suggested as significant predictors for lymphoma development among SS patients. Lipoprotein-associated phospholipase A2 (Lp-PLA2)-a product mainly of tissue macrophages-is found in the circulation associated with lipoproteins and has been previously involved in cardiovascular, autoimmune, and malignant diseases, including lymphoma.

Objective

The purpose of the current study was to investigate the contributory role of Lp-PLA2 in B-NHL development in the setting of primary SS.

Methods

Lp-PLA2 activity in serum samples collected from 50 primary SS patients with no lymph

SUBMITTER: Nezos A 

PROVIDER: S-EPMC8253309 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature