Ontology highlight
ABSTRACT:
SUBMITTER: Shimada Y
PROVIDER: S-EPMC8253403 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
PLoS genetics 20210622 6
Small non-protein coding RNAs are involved in pathways that control the genome at the level of chromatin. In Schizosaccharomyces pombe, small interfering RNAs (siRNAs) are required for the faithful propagation of heterochromatin that is found at peri-centromeric repeats. In contrast to repetitive DNA, protein-coding genes are refractory to siRNA-mediated heterochromatin formation, unless siRNAs are expressed in mutant cells. Here we report the identification of 20 novel mutant alleles that enabl ...[more]