Novel antibody-drug conjugates: current and future roles in gynecologic oncology.

ABSTRACT:

Purpose of review

Antibody-drug conjugates (ADCs) represent a new class of drugs that combine a surface receptor-targeting antibody linked to a cytotoxic molecule. This review summarizes the current literature demonstrating their tremendous promise as therapeutic agents in the treatment of aggressive gynecologic malignancies.

Recent findings

Several antigens have proven to be differentially overexpressed in a variety of gynecologic tumors when compared with normal surrounding tissue and serve as novel targets for ADC therapy. In the last few years HER2/neu, folic acid-alpha (FRα) and Trop-2 overexpression have been exploited as excellent targets by novel ADCs such as Trastuzumab emtansine (T-DM1), SYD985, IMGN853 (Mirvetuximab soravtansine) and Sacituzumab govitecan (SG, IMM

SUBMITTER: Tymon-Rosario J 

PROVIDER: S-EPMC8253558 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature