Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults: A Registry-Based Study.

ABSTRACT: Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. This study aims is to investigate the links between kidney function, kidney function decline and dementia incidence. We analyzed the association of eGFR with the risk of dementia (defined as a new dementia diagnosis or initiation of dementia treatments) among 329,822 residents of Stockholm who accessed healthcare during 2006-2011, were ≥65 years, had no history of dementia or underwent kidney replacement therapy. We also estimated the rate of eGFR decline among 205,622 residents with repeated eGFR measurements during the first-year of observation and investigated its association with subsequent dementia risk. 18,983 cases of dementia (5.8% of

SUBMITTER: Xu H 

PROVIDER: S-EPMC8253567 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature