Elevated risk of venous thromboembolism among post-traumatic brain injury patients requiring pharmaceutical immobilization.

ABSTRACT: Traumatic brain injury (TBI) patients are known to have a high rate of venous thromboembolism (VTE), and additional neuromuscular blockade or barbiturate coma therapy has the theoretical risk of exacerbating baseline hemostasis and elevating the incidence of thromboembolic events. We conducted a single-institution retrospective review of patients surviving severe TBI, as determined by need for intracranial pressure (ICP) monitoring, who further required paralytics or barbiturate therapy to maintain ICP control. Patients were administered VTE prophylaxis as clinically appropriate. Predictors for VTE were subsequently determined with univariate and logistic multivariate regression analyses. The main cohort includes 144 patients, 34 of whom received pharmaceutical immobilization for ICP contr

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8253589 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature