Study on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism.

ABSTRACT:

Background

Glioblastoma (GBM) is the most prevalent malignant tumor of the central nervous system (CNS). However, current GBM treatments are ineffective, signifying the great importance of exploring new therapeutic targets. Curcumin has been found to be a natural compound with an anticancer potential. However, its targets and mechanisms in GBM are still unclear.

Methods

Differentially expressed genes (DEGs) were screened from the GBM dataset in the GEO database and intersected with the target genes of curcumin to select potential target genes. Subsequently, survival analysis was performed with the GEPIA database to confirm the effect of target genes on the prognosis of GBM, and functional enrichment analysis was performed using the DAVID database. In vitro, CCK-8 assay was u

SUBMITTER: Su X 

PROVIDER: S-EPMC8253996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature