Differentially expressed proteins in platelets derived from patients with hypertension.

ABSTRACT: Hypertension (HTN) causes end-organ damage and is a major cause of morbidity and mortality globally. Recent studies suggested blood cells participate in the maintenance of HTN. Platelets-anucleated cell fragments derived from megakaryocytes-exert diverse functions, including their well-characterized role in the formation of hemostatic clots. However, platelets from patients with HTN exhibit altered membrane lipid and protein compositions that impact platelet function and lead to formation of aggregates and vascular obstructions. Here, for the first time, we have identified, by proteomic analyses, the most relevant 11 proteins that show the greatest difference in their expression in platelets derived from patients with HTN, in comparison with those from normotensive individuals. These prote

SUBMITTER: Armenta-Medina Y 

PROVIDER: S-EPMC8254060 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature