Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Over the past decades, many studies focused on mesenchymal stem cells (MSCs) therapy for bone regeneration. Due to the efficiency of topical application has been widely dicussed and systemic application was also a feasible way for new bone formation, the aim of this study was to systematically review systemic therapy of MSCs for bone regeneration in pre-clinical studies.

Methods

The article search was conducted in PubMed and Embase databases. Original research articles that assessed potential effect of systemic application of MSCs for bone regeneration in vivo were selected and evaluated in this review, according to eligibility criteria. The efficacy of MSC systemic treatment was analyzed by random effects meta-analysis, and the outcomes were expressed in standard

SUBMITTER: Fu J 

PROVIDER: S-EPMC8254211 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature