Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway.

ABSTRACT:

Background

Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 has been reported to be involved in stem cell induction and differentiation. However, whether Sox9-expressing cells play a role in radiation repair and regeneration remains unknown.

Methods

We successfully obtained Sox9^CreER, Rosa^tdTomato and Rosa^DTA mice and identified Sox9-expressing cells through lineage tracing. Then, we evaluated the effects of the ablation of Sox9-expressing cells in vivo. Furthermore, we investigated the underlying mechanism of Sox9-expressing cells during lung regeneration via an online single-cell RNA

SUBMITTER: Chen S 

PROVIDER: S-EPMC8254240 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature