The pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the most common type of liver cancer that occurs predominantly in patients with previous liver conditions. In the absence of an ideal screening modality, HCC is usually diagnosed at an advanced stage. Recent studies show that loss or gain of genomic materials can activate the oncogenes or inactivate the tumor suppressor genes to predispose cells toward carcinogenesis. Here, we evaluated both the copy number alteration (CNA) and RNA sequencing data of 361 HCC samples in order to locate the frequently altered chromosomal regions and identify the affected genes.

Results

Our data show that the chr1q and chr8p are two hotspot regions for genomic amplifications and deletions respectively. Among the amplified genes, YY1AP1 (chr1q22) poss

SUBMITTER: Shahrisa A 

PROVIDER: S-EPMC8254242 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature