Breast cancer cell line toxicity of a flavonoid isolated from Baccharis densiflora.

ABSTRACT:

Background

Flavonoids are compounds of interest in the search for new anti-cancer therapies. We have previously isolated the methoxyflavones 5,4'-dihydroxy-6,7,8,3'-tetramethoxyflavone (8-methoxycirsilineol), 5,4'-dihydroxy-6,7,8-trimethoxyflavone (xanthomicrol), and 5,4,'3'-trihydroxy-6,7,8-trimethoxyflavone (sideritoflavone) from Baccharis densiflora. Herein, we investigate the toxicity of these methoxyflavones in human breast-derived cell line. Our main aim was to focus on the cancer stem cell (CSC) sub-population of JIMT-1 breast cancer cells.

Methods

Initially, dose response experiments yielding inhibitory concentration 50 (IC₅₀) values were performed using MCF-7, HCC1937, and JIMT-1 breast cancer, and the MCF-10A normal-like breast cell lines to get an under

SUBMITTER: Sotillo WS 

PROVIDER: S-EPMC8254278 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature