Comparative cytokine profiling identifies common and unique serum cytokine responses in acute chikungunya and dengue virus infection.

ABSTRACT:

Background

Infection by chikungunya (CHIKV) and dengue virus (DENV) can cause a wide spectrum of clinical features, many of which are undifferentiated. Cytokines, which broadly also include chemokines and growth factors, have been shown to play a role in protective immunity as well as DENV and CHIKV pathogenesis. However, differences in cytokine response to both viruses remain poorly understood, especially in patients from countries where both viruses are endemic. Our study is therefore aimed to provide a comparative profiling of cytokine response induced by acute DENV and CHIKV infections in patients with similar disease stages and in experimental in vitro infections.

Methods

By using multiplex immunoassay, we compared host cytokine profiles between acute CHIKV and DENV inf

SUBMITTER: Dhenni R 

PROVIDER: S-EPMC8254284 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature