Small blood stem cells for enhancing early osseointegration formation on dental implants: a human phase I safety study.

ABSTRACT:

Background

Small blood stem cells (SB cells), isolated from human peripheral blood, demonstrated the ability to benefit bone regeneration and osseointegration. The primary goal of our study is to examine the safety and tolerability of SB cells in dental implantation for human patients with severe bone defects.

Methods

Nine patients were enrolled and divided into three groups with SB cell treatment doses of 1 × 10⁵, 1 × 10⁶, and 1 × 10⁷ SB cells, and then evaluated by computed tomography (CT) scans to assess bone mineral density (BMD) by Hounsfield units (HU) scoring. Testing was conducted before treatment and on weeks 4, 6, 8, and 12 post dental implantation. Blood and comprehensive chemistry panel testing were also performed.

Results

SUBMITTER: Feng SW 

PROVIDER: S-EPMC8254299 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature