SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.

ABSTRACT:

Background

Human tauopathies including Alzheimer's disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have been studied in detail, much less is known about the modification patterns of soluble Tau. Furthermore, PTMs other than phosphorylation have only come into focus recently and are still understudied. Soluble Tau species are likely responsible for the spreading of pathology during disease progression and are currently being investigated as targets for immunotherapies. A better understanding of their biochemical properties is thus of high importance.

Methods

We used a mass spectrometry approach

SUBMITTER: Bichmann M 

PROVIDER: S-EPMC8254302 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature