A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data.

ABSTRACT:

Background

X chromosome inactivation (XCI) is that one of two chromosomes in mammalian females is silenced during early development of embryos. There has been a statistical measure for the degree of the skewness of XCI for qualitative traits. However, no method is available for such task at quantitative trait loci.

Results

In this article, we extend the existing statistical measure for the skewness of XCI for qualitative traits, and the likelihood ratio, Fieller's and delta methods for constructing the corresponding confidence intervals, and make them accommodate quantitative traits. The proposed measure is a ratio of two linear regression coefficients when association exists. Noting that XCI may cause variance heterogeneity of the traits across different genotypes in female

SUBMITTER: Li BH 

PROVIDER: S-EPMC8254321 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature