Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.

ABSTRACT:

Background

Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China.

Methods

We aimed to investigate the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells. Between December 2012 and December 2014, a total of 310 single HPV16-positive samples were selected from women living in the Taizhou area, China. Sequences of all E6 and E7 oncogenes were analysed by PCR-sequencing assay. Detailed sequence comparison,

SUBMITTER: Dai MZ 

PROVIDER: S-EPMC8254333 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature