SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target.

ABSTRACT:

Background

The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes. Thus, modeling the immune microenvironment of colorectal cancer by analyzing the genes involved can be more conducive to the in-depth understanding of carcinogenesis and the progression thereof.

Methods

In this study, the number of stromal and immune cells in malignant tumor tissues were first estimated by using expression data (ESTIMATE) and cell-type identification with relative subsets of known RNA transcripts (CIBERSORT) to calculate the proportion of infiltrating immune cell and stromal components of colon cancer samples from the Cancer Genome Atlas database. Then the relationship

SUBMITTER: Wang S 

PROVIDER: S-EPMC8254339 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature