Comprehensive Analysis and Identification of an Immune-Related Gene Signature with Prognostic Value for Prostate Cancer.

ABSTRACT:

Background

The tumor microenvironment (TME) has recently been proven to play a crucial role in the development and prognosis of tumors. However, the current knowledge on the potential of the TME in prostate cancer (PCa) remains scarce.

Purpose

This study aims to elucidate the value of TME-related genes for PCa prognosis by integrative bioinformatics analysis.

Materials and methods

We downloaded the immune and stromal scores of PCa samples via the ESTIMATE and correlated these scores to clinicopathological characteristics and recurrence-free survival (RFS) of patients. Based on these scores, the TME-related differentially expressed genes were identified for functional enrichment analysis. Cox regression analyses were performed to identify prognostic genes and establish

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8254424 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature