The key amino acids of E protein involved in early flavivirus infection: viral entry.

ABSTRACT: Flaviviruses are enveloped viruses that infect multiple hosts. Envelope proteins are the outermost proteins in the structure of flaviviruses and mediate viral infection. Studies indicate that flaviviruses mainly use envelope proteins to bind to cell attachment receptors and endocytic receptors for the entry step. Here, we present current findings regarding key envelope protein amino acids that participate in the flavivirus early infection process. Among these sites, most are located in special positions of the protein structure, such as the α-helix in the stem region and the hinge region between domains I and II, motifs that potentially affect the interaction between different domains. Some of these sites are located in positions involved in conformational changes in envelope proteins. In

SUBMITTER: Hu T 

PROVIDER: S-EPMC8254458 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature