Circulating microRNAs as Potential Diagnostic Biomarkers for Poor Sleep Quality.

ABSTRACT:

Purpose

Persistent poor sleep quality leads to impaired cognitive performance and an inability to perform daily activities. Biomarker-assisted diagnosis is important for the early treatment of poor sleep quality; however, diagnostic biomarkers for poor sleep quality remain unidentified. Circulating microRNAs (miRNAs) have been reported to be linked to the pathogenesis of poor sleep quality, indicating their possible role in sleep problem diagnosis. The present study aimed to identify potential miRNA biomarkers for poor sleep quality.

Patients and methods

Differentially expressed serum miRNAs in patients with poor sleep quality and healthy controls (n=20) were analyzed via small RNA sequencing. Two-step quantitative RT-PCR in the two independent populations and receiver opera

SUBMITTER: Baek SJ 

PROVIDER: S-EPMC8254567 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature