Budesonide repairs decreased barrier integrity of eosinophilic nasal polyp epithelial cells caused by PM_2.5.

ABSTRACT:

Background

Eosinophilic chronic rhinitis with nasal polyps (eos-CRSwNP) is a subtype of nasal polyps (NPs) characterized by severe type-2 inflammation and defective epithelial barrier function. The epithelial barrier plays important roles in the pathogenesis of NPs and type-2 inflammation. Particular matter 2.5 (PM_2.5) are fine particles with a diameter less than 2.5 μm, containing a mixture of different components. Here, we investigated the impact of PM_2.5 on the barrier function of the eos-CRSwNP epithelium and explored the reparative function of budesonide.

Methods

Samples from noninflammatory nasal mucosa and eos-CRSwNP were collected to establish an in vitro air-liquid interface cultured model. The cells were exposed to PM_2.5 at 50 or 10

SUBMITTER: Ma S 

PROVIDER: S-EPMC8254582 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature