Skin sympathetic nerve activity as a biomarker for neurologic recovery during therapeutic hypothermia for cardiac arrest.

ABSTRACT:

Background

Targeted temperature management (TTM) improves neurologic outcome after cardiac arrest. However, better neurologic prognostication is needed.

Objective

The purpose of this study was to test the hypothesis that noninvasive recording of skin sympathetic nerve activity (SKNA) and its association with heart rate (HR) during TTM may serve as a biomarker of neurologic status.

Methods

SKNA recordings were analyzed from 29 patients undergoing TTM. Patients were grouped based on Clinical Performance Category (CPC) score into group 1 (CPC 1-2) representing a good neurologic outcome and group 2 (CPC 3-5) representing a poor neurologic outcome.

Results

Of the 29 study participants, 18 (62%) were deemed to have poor neurologic outcome. At all timepoints, low aver

SUBMITTER: Kutkut I 

PROVIDER: S-EPMC8254741 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature