Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms.

ABSTRACT:

Purpose of review

Thrombosis remains a leading cause of morbidity and mortality in BCR/ABL negative myeloproliferative neoplasms (MPN). Circulating blood cells are both increased in quantity and qualitatively abnormal in MPN, resulting in an increased thrombotic risk. Herein, we review recently elucidated mechanisms of MPN thrombosis and discuss implications of drugs currently under investigation for MPN.

Recent findings

Recent studies highlight that in JAK2^V617F granulocytes and platelets, thrombo-inflammatory genes are upregulated. Furthermore, in JAK2^V617F granulocytes, protein expression of integrin CD11b, tissue factor, and leukocyte alkaline phosphatase are all increased. Overall, myeloid cells, namely neutrophils, may contribute in several ways,

SUBMITTER: Reeves BN 

PROVIDER: S-EPMC8254753 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature