A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States.

ABSTRACT:

Background

We investigated the association between reproductive risk factors and breast cancer subtype in Black women. On the basis of the previous literature, we hypothesized that the relative prevalence of specific breast cancer subtypes might differ according to reproductive factors.

Methods

We conducted a pooled analysis of 2,188 (591 premenopausal, 1,597 postmenopausal) Black women with a primary diagnosis of breast cancer from four studies in the southeastern United States. Breast cancers were classified by clinical subtype. Case-only polytomous logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for HER2⁺ and triple-negative breast cancer (TNBC) status in relation to estrogen receptor-positive (ER⁺)/HER2^-</

SUBMITTER: Sanderson M 

PROVIDER: S-EPMC8254754 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature