Perinatal exposure to maternal smoking and adulthood smoking behaviors in predicting cardiovascular diseases: A prospective cohort study.

ABSTRACT:

Background and aims

Little is known about the associations between perinatal exposure to maternal smoking and cardiovascular disease (CVD) incidence in offspring, and whether such associations are modified by adulthood and genetically determined smoking behaviors.

Methods

A total of 414,588 participants without CVD at baseline were included from the UK Biobank in 2006-2010 and followed up through 2018. Cox-proportional hazard models were used to examine the association of perinatal maternal smoking with CVD, and both multiplicative and additive interaction analyses were performed to investigate the modification effects of own smoking behaviors.

Results

During a median follow-up of 8.93 years, we observed 10,860 incident CVD events, including 7006 myocardial infarction

SUBMITTER: Song Q 

PROVIDER: S-EPMC8254766 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature