Tobacco Smoking and the Fecal Microbiome in a Large, Multi-ethnic Cohort.

ABSTRACT:

Background

Increasing evidence suggests that tobacco smoking, a well-known driver of carcinogenesis, influences the gut microbiome; however, these relationships remain understudied in diverse populations. Thus, we performed an analysis of smoking and the gut microbiome in a subset of 803 adults from the multi-ethnic NYU FAMiLI study.

Methods

We assessed fecal microbiota using 16S rRNA gene sequencing, and clustered samples into Amplicon Sequence Variants using QIIME2. We evaluated inferred microbial pathway abundance using PICRUSt. We compared population β-diversity, and relative taxonomic and functional pathway abundance, between never smokers, former smokers, and current smokers.

Results

We found that the overall composition of the fecal microbiome in former and cur

SUBMITTER: Prakash A 

PROVIDER: S-EPMC8254769 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature