Solid Organ Transplantation and Survival among Individuals with a History of Cancer.

ABSTRACT:

Background

The success of immunotherapy highlights a possible role for immunity in controlling cancer during remission for patients with cancer in the general population. A prior cancer diagnosis is common among solid organ transplant candidates, and immunosuppressive medications administered to transplant recipients may increase recurrence risk.

Methods

Using linked data from the United States solid organ transplant registry and 13 cancer registries, we compared overall and cancer-specific survival among patients with cancer who did versus did not receive subsequent transplantation. We used Cox regression in cohort and matched analyses, controlling for demographic factors, cancer stage, and time since cancer diagnosis.

Results

The study included 10,524,326 patients w

SUBMITTER: Engels EA 

PROVIDER: S-EPMC8254777 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature