Corneal sub-basal nerve plexus microneuromas in individuals with and without dry eye.

ABSTRACT:

Background/aim

An objective marker is needed to detect when corneal nerve abnormalities underlie neuropathic corneal pain (NCP), as symptoms often overlap with those of dry eye (DE). This study evaluated microneuroma (MN) frequency in various populations and investigated relationships between MN presence and DE clinical features in individuals with DE symptoms but without a history of refractive surgery, in order to eliminate refractive surgery as a potential confounder of nerve abnormalities.

Methods

This was a retrospective study that included individuals with and without DE symptoms who underwent a clinical evaluation for DE (symptom surveys and ocular surface evaluation) and in vivo confocal microscopy imaging. DE clinical features (including those suggestive of neuropat

SUBMITTER: Dermer H 

PROVIDER: S-EPMC8254821 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature