Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.

ABSTRACT: Homer1 is a synaptic scaffold protein that regulates glutamatergic synapses and spine morphogenesis. HOMER1 knockout (KO) mice show behavioral abnormalities related to psychiatric disorders, and HOMER1 has been associated with psychiatric disorders such as addiction, autism disorder (ASD), schizophrenia (SZ), and depression. However, the mechanisms by which it promotes spine stability and its global function in maintaining the synaptic proteome has not yet been fully investigated. Here, we used computational approaches to identify global functions for proteins containing the Homer1-interacting PPXXF motif within the postsynaptic compartment. Ankyrin-G was one of the most topologically important nodes in the postsynaptic peripheral membrane subnetwork, and we show that one of the PPXXF moti

SUBMITTER: Yoon S 

PROVIDER: S-EPMC8254828 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature