Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population.

ABSTRACT: Runs of homozygosity (ROH) arise when an individual inherits two copies of the same haplotype segment. While ROH are ubiquitous across human populations, Native populations-with shared parental ancestry arising from isolation and endogamy-can carry a substantial enrichment for ROH. We have been investigating genetic and environmental risk factors for alcohol use disorders (AUD) in a group of American Indians (AI) who have higher rates of AUD than the general U. S. population. Here we explore whether ROH might be associated with incidence and severity of AUD in this admixed AI population (n = 742) that live on geographically contiguous reservations, using low-coverage whole genome sequences. We have found that the genomic regions in the ROH that were identified in this population had signif

SUBMITTER: Peng Q 

PROVIDER: S-EPMC8254832 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature