A transgenic system for targeted ablation of reproductive and maternal-effect genes.

ABSTRACT: Maternally provided gene products regulate the earliest events of embryonic life, including formation of the oocyte that will develop into an egg, and eventually into an embryo. Forward genetic screens have provided invaluable insights into the molecular regulation of embryonic development, including the essential contributions of some genes whose products must be provided to the transcriptionally silent early embryo for normal embryogenesis, called maternal-effect genes. However, other maternal-effect genes are not accessible due to their essential zygotic functions during embryonic development. Identifying these regulators is essential to fill the large gaps in our understanding of the mechanisms and molecular pathways contributing to fertility and to maternally regulated developmental p

SUBMITTER: Bertho S 

PROVIDER: S-EPMC8254866 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature