DNA integrity in diagnosis of premalignant lesions.

ABSTRACT:

Background

Carcinogenesis is a dynamic process which traditional biopsying can not keep up with. Saliva as fluid in the vicinity of the tumor can offer better insights to this process. This study aimed to identify the accuracy of salivary DNA integrity index in differentiating between oral premalignant lesions and oral cancer.

Material and methods

This phase II diagnostic test accuracy study included 93 patients divided into three groups: 30 oral cancer patients, 33 patients with oral premalignant lesions divided into 21 oral lichen planus patients and 12 patients with leukoplakia and 30 normal individuals who acted as controls. Oral rinse was collected from all participants and they all underwent conventional visual and tactile examination, and patients with oral lesions ha

SUBMITTER: Azab NA 

PROVIDER: S-EPMC8254884 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature