Maternal cold exposure induces distinct transcriptome changes in the placenta and fetal brown adipose tissue in mice.

ABSTRACT:

Background

Brown adipose tissue (BAT) is specialized to dissipate energy in the form of heat. BAT-mediated heat production in rodents and humans is critical for effective temperature adaptation of newborns to the extrauterine environment immediately after birth. However, very little is known about whether and how fetal BAT development is modulated in-utero in response to changes in maternal thermal environment during pregnancy. Using BL6 mice, we evaluated the impact of different maternal environmental temperatures (28 °C and 18 °C) on the transcriptome of the placenta and fetal BAT to test if maternal cold exposure influences fetal BAT development via placental remodeling.

Results

Maternal weight gain during pregnancy, the average number of fetuses per pregnancy, and placen

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC8254942 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature