Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition.

ABSTRACT:

Background

Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer's disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid deposition is associated with neuroinflammation and cognitive deficits, we studied brain inflammatory cytokine expression and cognitive decline in non-demented elderly individuals with and without cerebral amyloid-beta deposition.

Methods

Global cognition, episodic, working, and semantic memory, perceptual speed, visuospatial ability, and longitudinal decline (5.7 ± 3.6 years) in each cognitive domain were compared between elderly individuals (66-79 years) with and without cerebral amyloid-beta deposition. The expression of 20 inflammatory cytokines was analyzed

SUBMITTER: Flores-Aguilar L 

PROVIDER: S-EPMC8254948 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature