Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.

ABSTRACT:

Background

Antibiotic-resistance reduces the efficacy of conventional triple therapy for Helicobacter Pylori infections worldwide, which necessitates using various treatment protocols. We used two protocols, doxycycline-based quadruple regimen and concomitant levofloxacin regimen. The aim was to assess the effectiveness of doxycycline-based quadruple regimen for treating Helicobacter Pylori infections compared with levofloxacin concomitant regimen as empirical first-line therapy based on intention-to-treat (ITT) and per-protocol analyses (PPA) in Syrian population.

Settings and design

An open-label, randomised, parallel, superiority clinical trial.

Methods

We randomly assigned 78 naïve patients who tested positive for Helicobacter Pylori gastric infection, with a 1:1

SUBMITTER: Alhalabi M 

PROVIDER: S-EPMC8254989 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature