Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity. However, the functional role of antibody-dependent immune response against antigens present in the damaged vessel remains unresolved. We hypothesized that engagement of immunoglobulin G (IgG) Fc receptors (FcγR) by immune complexes (IC) in the aortic wall contributes to AAA development. We therefore evaluated FcγR expression in AAA lesions and analysed whether inhibition of FcγR signaling molecules (γ-chain and Syk kinase) influences AAA formation in mice.

Methods

FcγR gene/protein expression was assessed in human and mouse AAA tissues. Experimental AAA was induced by a

SUBMITTER: Lopez-Sanz L 

PROVIDER: S-EPMC8255062 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature