Luteolin inhibits H₂O₂-induced cellular senescence via modulation of SIRT1 and p53.

ABSTRACT: Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H₂O₂)-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated β-galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependen

SUBMITTER: Zhu RZ 

PROVIDER: S-EPMC8255127 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature