Systemic acidemia impairs cardiac function in critically Ill patients.

ABSTRACT:

Background

Acidemia, is associated with reduced cardiac function in animals, but no studies showing an effect of acidemia on cardiac function in humans are reported. In the present study, we examined the effect of acidemia on cardiac function assessed with transpulmonary thermodilution technique with integrated pulse contour analysis (Pulse Contour Cardiac Output, PiCCO™) in a large cohort of critically ill patients.

Methods

This was a prospective multicenter observational cross-sectional study of 297 patients from 6 intensive care units in London, England selected from all patients admitted consecutively between May 2018 and March 2019. Measurements of lowest plasma pH and concurrent assessment of cardiac function were obtained.

Findings

There was a significant diffe

SUBMITTER: Rodriguez-Villar S 

PROVIDER: S-EPMC8255172 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature