Automated production of [¹⁸F]Flortaucipir for PET imaging of tauopathies.

ABSTRACT: Radiotracer [¹⁸F]Flortaucipir is an FDA-approved diagnostic agent for PET imaging of density and distribution of abnormal tau protein deposition (tauopathies) in Alzheimer's disease. A high-yield automated method for routine GMP-compliant [¹⁸F]Flortaucipir production is desired to meet increasing clinical need. In this work, we reported an automated radiosynthesis of [¹⁸F]Flortaucipir in a RNplus Research module and the quality control (QC) tests for human use under full GMP compliance. Briefly, automated radiosynthesis of [¹⁸F]Flortaucipir was processed via nucleophilic radiofluorination of precursor AV1622 and followed by acid hydrolysis in a RNplus Research module, which included the radiosynthesis, semi-preparative high-performance liquid chr

SUBMITTER: Jiang H 

PROVIDER: S-EPMC8255216 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature