Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.

ABSTRACT:

Objective

To study genetic variants and their function within genes coding for complement receptors in pre-eclampsia.

Design

A case-control study.

Setting

Pre-eclampsia is a common vascular disease of pregnancy. The clearance of placenta-derived material is one of the functions of the complement system in pregnancy.

Population

We genotyped 500 women with pre-eclamptic pregnancies and 190 pregnant women without pre-eclampsia, as controls, from the FINNPEC cohort, and 122 women with pre-eclamptic pregnancies and 1905 controls from the national FINRISK cohort.

Methods

The functional consequences of genotypes discovered by targeted exomic sequencing were explored by analysing the binding of the main ligand iC3b to mutated CR3 or CR4, which were transiently e

SUBMITTER: Lokki AI 

PROVIDER: S-EPMC8255276 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature