Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria.

ABSTRACT:

Purpose

Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases.

Methods

We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay.

Results

Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune di

SUBMITTER: Kolkhir P 

PROVIDER: S-EPMC8255350 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature