Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK Asthmatics.

ABSTRACT:

Purpose

Although genome-wide association studies (GWASs) represent the most powerful approach for identifying genes that influence asthma, to date, no studies have established genetic susceptibility to asthma in the Korean population. This study aimed to identify genetic variants associated with adult Korean asthmatics and compare them with the significant single nucleotide polymorphisms (SNPs) of UK asthmatics from the UK Biobank.

Methods

Patients were defined as having asthma if they were diagnosed by a doctor or taking medications for asthma. Controls were defined as individuals without asthma or chronic obstructive pulmonary disease. We performed quality control, genotype imputation, GWAS, and PrediXcan analyses. In the GWAS, a P value of < 5 × 10^-8 was

SUBMITTER: An J 

PROVIDER: S-EPMC8255356 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature